Abstract
Sixteen pigs aged 5 to 7 weeks were inoculated intranasally with the pneumotropic strain 4892 of Aujeszky's disease virus (ADV) in a dose of 2 x 10(5) TCID50. Pigs died or were killed on day 4, 5, 6, 7, 8, 10, 12, 20 or 30 post-inoculation (PI). Two further pigs were kept as negative (uninfected) controls. Histopathological examination demonstrated meningoencephalitis, necrotizing rhinitis and multifocal systemic necrosis. Viral antigen was detected immunohistochemically, mainly in the central nervous system up to day 12 PI, and to a lesser degree in the lung, nasal mucosa and tonsil. ADV DNA was detected at days 20 and 30 PI by a nested polymerase chain reaction technique. This study indicated that the spread of the highly virulent, pneumotropic strain 4892 did not differ from that of other neurotropic or pneumotropic ADV strains.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
