Abstract
This study assessed the immunoexpression of extracellular matrix metalloproteinase inducer (EMMPRIN) and the angiogenic index between odontogenic lesions. Study Design: The sample was composed of 20 cases each of radicular cysts (RCs), dentigerous cysts (DCs), and odontogenic keratocysts (OKCs). Immunoexpression of EMMPRIN was evaluated in the epithelial component and connective tissue of the lesions. Angiogenic index was determined by microvessel count (MVC) using anti-CD105 antibody. Results: Expression of EMMPRIN in the epithelial lining did not differ significantly between groups (p > 0.05). In the fibrous capsule, immunostaining for EMMPRIN showed a significant difference for RCs (p < 0.001). MVC revealed a significant difference between RCs and OKCs (p = 0.018). Positive and moderate correlation was observed between MVC and immunoexpression of EMMPRIN in the fibrous capsule of RCs (r = 0.654; p = 0.002). Conclusion: The results suggest that the expression of EMMPRIN is related to the development of the odontogenic lesions studied.
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