Abstract
The changes in small cell carcinoma of the lung (SCLC) in response to chemotherapy and/or radiotherapy were examined immunohistochemically. Epithelial and neuroendocrine markers were analyzed in eight patients with SCLCs who had preoperative adjuvant therapy and in 18 who did not have preoperative therapy. In the former group, five patients had chemotherapy only, two had radiotherapy only, and one had both radiotherapy and chemotherapy. Keratin and secretory component (SC) were used as markers of epithelial cells, and gastrin releasing peptide (GRP), neuron specific enolase (NSE), and Leu 7 were used as markers of neuroendocrine cells. There were no differences in percentages of positive staining for keratin, SC, NSE, and Leu 7 between the two groups. On the other hand, fewer patients who had received preoperative adjuvant therapy showed positive staining for GRP than those without preoperative therapy. It appears that the neuroendocrine nature expressed by GRP was decreased in SCLC by chemotherapy and/or radiotherapy.
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