Abstract
Background The aim of this research was to study anti-microbial and anti-inflammatory characteristics of silver nanoparticles helping bone structures to recover during late stage of parodontitis, which afterwards will increase the effect of bone regeneration operations. Material and Methods We assessed colloid solution-derived silver nanoparticles coating of polylactic acid membrane regarding tissue foreign body response. Thirty eight polylactic acid membranes were implanted intracranially in rabbits – ten unmodified (control group) and twenty eight with silver nanoparticles coating (experimental group). In controls, penicillin was used for infection prophylaxis. Tissue response was assessed by light microscopy and immunohistochemistry (CD3, CD15, CD30) 2 weeks after implantation. Results inflammation markers in experimental group were significantly lower than in control group, there were no signs of forming a fibrosis capsule nor infectious signs. Conclusions colloid silver solution can be used as a source of nanoparticles for anti-microbial and anti-inflammatory biodegradable membranes’ coating. Key words:Guided bone regeneration, polylactic acid membrane, silver nanoparticles.
Highlights
Up to date, bone tissue loss is a challenging problem in periodontal disease and maxillofacial surgery [1,2,3]
Background: The aim of this research was to study anti-microbial and anti-inflammatory characteristics of silver nanoparticles helping bone structures to recover during late stage of parodontitis, which afterwards will increase the effect of bone regeneration operations
We describe colloid silver nanoparticles as a source of effective anti-microbial and anti-inflammatory biodegradable membranescoating
Summary
Bone tissue loss is a challenging problem in periodontal disease and maxillofacial surgery [1,2,3]. Non-degradable barrier membranes has been shown to prevent resorption of bone grafts, the inevitable need for the re-operation to remove the membrane remains a recognized drawback [2] This problem is solved by using biodegradable materials such as polylactic acid (PLA) membranes. The study aimed to assess anti-inflammatory and antimicrobial properties of polylactic acid membranes modified with colloid solution-derived silver nanoparticles. The aim of this research was to study anti-microbial and anti-inflammatory characteristics of silver nanoparticles helping bone structures to recover during late stage of parodontitis, which afterwards will increase the effect of bone regeneration operations. Material and Methods: We assessed colloid solution-derived silver nanoparticles coating of polylactic acid membrane regarding tissue foreign body response. Conclusions: colloid silver solution can be used as a source of nanoparticles for anti-microbial and anti-inflammatory biodegradable membranes’ coating
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