Abstract
Tensins belong to the group of adhesion proteins that are involved in cell adhesion and migration, actin cytoskeleton maintenance and intercellular communication. TNS1, TNS2 and TNS3 proteins expression was evaluated in 90 patients with gastric cancer by immunohistochemistry method. TNS1 was more frequently present in non-differentiated tumors compared to poorly and moderately differentiated tumors (p = 0.016). TNS1 was also more often observed in metastatic tumors compared to those without distant metastases (p = 0.001). TNS2 was more common in moderately differentiated tumors than in poorly or non-differentiated ones (p = 0.041). TNS2 expression was also more frequently present in tumors with peritumoral inflammation (p = 0.041) and with concomitant H. pylori infection (p = 0.023). In contrast, TNS3 protein was more prevalent in moderately than in poorly and non-differentiated tumors (p = 0.023). No significant relationship was found between tensins’ expression and the overall survival rate of patients. TNS1 protein expression is associated with a poor-prognosis type of GC. Higher expression of TNS2 is accompanied by peritumoral inflammation and H. pylori infection, which favor the development of GC of a better prognosis, similarly to higher TNS3 protein expression.
Highlights
Gastric cancer (GC) contributes to the death of nearly 6% of malignant cancer patients worldwide, which makes it the fifth cause of death caused by various cancers [1].gastric cancer (GC) affects men more frequently than women and is more and more often diagnosed in young people (
The expression of the tensins was higher in cancer cells compared to normal gastric mucosa cells
A microscopic analysis demonstrated that positive expression of TNS1, TNS2 and TNS3 proteins in tumor cells was present in 7 (7.78%), 4 (4.44%) and 32 (35.56%) out of 90 patients, respectively
Summary
Gastric cancer (GC) contributes to the death of nearly 6% of malignant cancer patients worldwide, which makes it the fifth cause of death caused by various cancers [1].GC affects men more frequently than women and is more and more often diagnosed in young people (
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