Immunohistochemical analysis of local immunity in salmonella and shigella infections

Abstract

The persistent tendency for an increase in the frequency of subacute and chronic forms, and also the existence of a carrier state of the microorganisms responsible for dysentery and salmonella infections are associated with the characteristics of immunity to these infections [3, 4]. It was shown previously that the enzyme status of the immunocytes of the intestinal mucous membrane has characteristic differences both in the dynamics of the acute infectious process and in the chronic course of the disease, and that this can be used as a test for the detection of disturbance of the immune response [1, 2]. However, the study of the cellular enzyme status (CES) does not explain the role of individual lymphocyte subpopulations in the local immune response. Immunohistochemical analysis of cells of the immune system in the mucous membrane of the digestive organs has enabled the mechanisms of disturbances of the immune response to be studied in different infections and approaches to their correction substantiated [5]. The aim of this investigation was an immunohistochemical analysis of the local immune response, compared with the CES of immunocytes in the mucous membrane of the large intestine in different forms of shigella and salmonella infections.