Abstract
Objective: To evaluate the immunoexpression of autophagy-related proteins (p62 and Atg7) in odontogenic keratocysts associated with Gorlin syndrome (SOKCs) and nonsyndromic odontogenic keratocysts (NSOKCs).Study design: The percentages of immunopositive cells (nuclear and cytoplasmic/membrane) for p62 and Atg7 in the epithelial component of 25 SOKCs and 25 NSOKCs were assessed. The results were analyzed statistically using the nonparametric Mann-Whitney U test and Spearman correlation test. Results: Expression of p62 and Atg7 was observed in all cases studied. Compared with NSOKCs, SOKCs exhibited higher nuclear expression of p62 (P< .001) and Atg7 (P< .001). No significant difference in the cytoplasmic/membrane expression of p62 was observed between groups (P = .594). On the other hand, SOKCs exhibited higher cytoplasmic/membrane expression of Atg7 compared with NSOKCs (P< .001). In NSOKCs, positive correlations were observed between cytoplasmic/membrane expressions of Atg7 and p62 (P = .004). In SOKCs, positive correlations were found between nuclear and cytoplasmic/membrane expressions of Atg7 and p62 (P< .05).Conclusion: The results suggest a potential role of autophagy in the pathogenesis of odontogenic keratocysts. The more aggressive biological behavior of SOKCs compared with NSOKCs may be related to increased nuclear translocation of p62 and higher cytoplasmic/membrane expression of Atg7. Financial support: CNPq (427931/2016-9). Objective: To evaluate the immunoexpression of autophagy-related proteins (p62 and Atg7) in odontogenic keratocysts associated with Gorlin syndrome (SOKCs) and nonsyndromic odontogenic keratocysts (NSOKCs).Study design: The percentages of immunopositive cells (nuclear and cytoplasmic/membrane) for p62 and Atg7 in the epithelial component of 25 SOKCs and 25 NSOKCs were assessed. The results were analyzed statistically using the nonparametric Mann-Whitney U test and Spearman correlation test. Results: Expression of p62 and Atg7 was observed in all cases studied. Compared with NSOKCs, SOKCs exhibited higher nuclear expression of p62 (P< .001) and Atg7 (P< .001). No significant difference in the cytoplasmic/membrane expression of p62 was observed between groups (P = .594). On the other hand, SOKCs exhibited higher cytoplasmic/membrane expression of Atg7 compared with NSOKCs (P< .001). In NSOKCs, positive correlations were observed between cytoplasmic/membrane expressions of Atg7 and p62 (P = .004). In SOKCs, positive correlations were found between nuclear and cytoplasmic/membrane expressions of Atg7 and p62 (P< .05).Conclusion: The results suggest a potential role of autophagy in the pathogenesis of odontogenic keratocysts. The more aggressive biological behavior of SOKCs compared with NSOKCs may be related to increased nuclear translocation of p62 and higher cytoplasmic/membrane expression of Atg7. Financial support: CNPq (427931/2016-9).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
