Abstract
When an arbovirus enters its arthropod host during a viremic blood meal it quickly reaches the midgut where virus penetration of the host parenchyma and infection of epithelial cells apparently occur. Subsequently, viral particles enter the arthropod's hemolymph and are transported to other tissues which may then become infected. Previous studies have demonstrated that when the arbovirus reaches the salivary glands it increases in titer and persists over long periods, often throughout the life of the vector.It is this persistent presence and associated continual shedding of virus into saliva which is one reason that certain arthropods are extremely efficient biological vectors.Culicoides variipennis(Coquillett) is probably the most economically important species of biting midge in the U.S. due to its involvement in the transmission of bluetongue (BT) disease of sheep, cattle and ruminant wildlife. Although there have been numerous electron microscopic studies of many mosquito-borne viruses in their natural hosts, virtually nothing is known about the replicative cycle of BTV in the salivary glands of its primary vector.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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