Abstract
As one of active immune effector molecules, immunoglobulins play an important role in the pathogenesis, diagnosis and treatment of autoimmune bullous diseases. Human immunoglobulins can be divided into 5 categories, including IgG, IgA, IgM, IgD and IgE, and all of them participate in and play different roles in the pathogenesis of autoimmune bullous diseases except IgD. IgG can induce the formation of blisters by activating complements and leukocytes as well as by releasing proteolytic enzymes, and different subtypes of IgG differ in biological activities. IgA can cause granulocyte migration and lead to the formation of blisters and pustules. IgE is associated with urticaria-like erythema and eosinophil infiltration. IgM is usually seen in Brazilian pemphigus foliaceus. These findings may provide new ideas for the diagnosis and treatment of autoimmune bullous diseases. Key words: Skin diseases, vesiculobullous; Immunoglobulins; Antibodies; Autoimmunity; Diagnosis
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