Abstract
Concentrations of immunoglobulins G, A, and M were studied in 120 patients with acute leukemia 7 months to 16 years of age. Eighty-three had acute stem cell leukemia (ALL) and 37 had acute myelogenous, monocytic, or atypical leukemia. The initial concentrations of all three immunoglobulins in ALL tend to be low in spite of the prevalence of infection. Further decreases occurred after induction of remission, but thereafter the concentrations increased to reach pretherapy values despite maintenance therapy. In patients who were receiving periodic irradiation to the central nervous system the IgA levels were significantly lower than in patients not so treated, but the incidence of intercurrent infections was not significantly altered. In the group of myelogenous or atypical leukemias, high or normal initial concentrations of immunoglobulins were found in all but two patients at diagnosis. The trend during induction and maintenance of remission followed the same pattern as in ALL. Levels of IgG below 350–380 mg/dl had a bad prognostic significance.
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