Abstract
Abstract The serum antibody response of 23 individuals with adenovirus infection (types 4, 1, 6 and 7) was studied. Neutralizing antibody tests correlated well with radioimmunodiffusion; the latter technique, however, offered the advantages of simplicity and distinct separation of specific immunoglobulin antibodies. The antigen used in radioimmunodiffusion measured group—rather than type—specific adenovirus antibody. Only four patients exhibited the early appearance of macroglobulin antibody in the serum followed by and then replaced by IgG. The majority of individuals showed a prolonged IgM response accompanied by high titered IgG antibody. IgA serum antibody developed in almost all the patients. Following type 4 adenovirus infection, nasal secretory antibodies, both IgA and IgG but not IgM, were detected at the same time or within a week of the detection of serum antibody, and were universally found in the 35 individuals who were studied.
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