Immunoglobulin profile of the mucous membranes of the large intestine in lambs in early postnatal ontogenesis

Abstract

The paper presents data reflecting the dynamics of immunoglobulins of classes G and A in the mucous membrane of the blind, colon and rectum of lambs in colostrum, milk and mixed periods of nutrition, compared with similar data of sheep 3-5 years of age. Various biotopes of the digestive system of animals perform not only the digestive, but also a protective function. It is known that about 80% of all immunocompetent cells of organism are located in the mucous membrane of the small and large intestines in sheep. An important role in protecting against pathogens is played by various classes of immunoglobulins, the dynamics and functions of which, in the mucous membrane of the cecum, colon and rectum of sheep, are still being debated. In connection with the foregoing, the aim of the work was to quantitatively characterize IgG and IgA in the mucous membranes of the large intestine and their functional relationship with microflora (Bifidobacterium). In lambs, during the period of early postnatal ontogenesis in the mucous membrane of the large intestine, the content of immunoglobulins of classes G and A is different. It was established that the level of IgG and the quantitative content of bifidobacterium in the large intestine are functionally independent; in the colon and rectum, IgA and Bifidobacterium correlate. Thus, the concentration of IgG depends on the flow of colostrum into the intestines of the lamb in the first day after birth, and the level of IgA from colonization of the large intestine by dominant microflora.