Abstract

Abstract Combined studies of direct membrane immunofluorescence with anti-immunoglobulin serum and of lymphocyte blastogenic responses to autologous leukemia cells were carried out in 34 adult patients with acute leukemia. Twenty-four of 34 (71 per cent) has positive blastogenic responses to their own leukemia cells. Eight of 19 patients with acute myelogenous leukemia and one of five with acute lymphoblastic leukemia had complete or partial abrogation of this positive blastogenesis when the lymphocytes were cultured in autologous rather than allogeneic serum. Direct membrane immunofluorescence with anti-immunoglobulin serum showed bound IgG on the cells of seven of eight patients with acute myelogenous leukemia and serum inhibition, and one without the serum inhibitory effect. Membrane immunofluorescence was negative in two patients with positive blastogenesis and serum inhibition, 14 of 15 with positive blastogenesis and no serum inhibition and, finally, all 10 patients with negative blastogenic respons...

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