Abstract
The immunoglobulin genes are built from variable, joining, and constant gene segments (V, J, C). The V and J+C gene segments are separate in germline DNA and are brought into close proximity in the immunoglobulin-producing lymphoid cells. Antibody diversity rests mainly on the existence of many different V and several different J gene segments, on the variability in the exact points of joining of the gene segments, and on a somatic hypermutation mechanism. The early work from our laboratory on the structure and expression of immunoglobulin genes has been reviewed [1].
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