Abstract
Switching of an Abelson virus-transformed mouse lymphoid cell line from immunoglobulin mu to gamma 2b heavy-chain synthesis in vitro is accompanied by loss of DNA sequences between the JH and C gamma 2b gene segments, and thus cannot be explained by differential RNA processing. The light-chain loci of both mu- and gamma 2b-producing cell clones are in the embryonic configuration, which indicates that class switching can occur in pre-B cells.
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