Abstract
Background and objectives: It is well known that children with Down syndrome (DS) suffer from frequent infections. There is an association of certain IgG subclass abnormalities with the predisposition to recurrent infection of the respiratory tract. Therefore, the study was conducted to determine the immunoglobulin G1 and G2 (IgG1, IgG2) profile in children with DS.Material and methods: Forty children between the ages of 6 months to 12 years with DS (47 XX/XY, +21) attending the Department of Immunology, BIRDEM were enrolled in the study. Age and sex matched 30 healthy normal children with 46 XX/XY were included as control. Enrolled DS and healthy children were divided into two age groups namely 6 months to 6 years and 7 years to 12 years. Serum IgG1 and IgG2 concentrations were determined by enzyme linked immunosorbent assay (ELISA) method.Results: The mean serum IgG1 concentrations of children with DS in both age groups did not differ significantly from that of normal healthy children. But the IgG2 level was significantly less (p<0.003 and p<0.004) in both age groups of children with DS compared to that of control healthy children.Conclusion: The study has demonstrated that the serum IgG2 level was significantly less in children with DS than that of matched normal healthy control children while there was no deficiency of IgG1.IMC J Med Sci 2017; 11(1): 1-4
Highlights
Down syndrome (DS) is one of the most common autosomal disorders
We have demonstrated that in our DS group the serum IgG2 level was significantly less (p
Along with the estimation of total IgG, it is important to determine the levels of all IgG subclasses to ascertain the specific abnormalities
Summary
02 IMC J Med Sci 2017; 11(1): 1-4 subclass IgG1 and IgG3 are more potent opsonizers than that of IgG2 and igG4 [9]. IgG1and IgG3 is generally produced in response to protein antigens of bacteria, viruses, vaccines and foods. IgG2 antibodies predominantly act against carbohydrate antigens and are important in protection against polysaccharide encapsulated organisms such as Streptococcus pneumoniae, Haemophilus influenzae and Neisseria meningitides [10]. To date there is no study on immunoglobulin subclass pattern among Bangladeshi children with DS. The present study was conducted to determine the IgG1 and IgG2 profile of Bangladeshi children with DS and whether they are different in comparison to normal children of the same age group
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