Abstract
Abstract Facilitation of localized hemolysis-in-agar plaque-forming cells (PFC) using antisera specific for each of the five immunoglobulin classes of mice (IgM, IgA, γ1, γ2a and γ2b) reveals that the peak production of IgM (direct) PFC in the spleens of mice occurs 4 days after receiving an optimal dose of sheep erythrocytes and is followed in 24 hr by the appearance of PFC representing each of the 7S immunoglobulin classes (IgA, γ1, γ2a and γ2b). while the number of direct (IgM) PFC falls after reaching a peak on day 4, 7S immunoglobulin antibody producing cells (indirect plaques) appear, decline and reappear in phases. 7S immunoglobulin antibody-producing cells appear more rapidly and in greater numbers in the secondary response, while direct (IgM) PFC are found in fewer numbers in the secondary response than in the primary response. However, indirect IgM PFC, apparently due to the production of IgM hemolysin of “low efficiency,” are a prominent feature of the secondary response.
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