Abstract
Acute leukemias are commonly classified on the basis of morphologic, cytochemical and immunologic criteria. Immunologic techniques, particularly surface antigen analysis using monoclonal antibodies, have related leukemic cells to normal cell counterparts [1]. In general, lineage fidelity is maintained in leukemic blast cells. However, there are exceptions [2, 3]. Recently, molecular analysis using specific Ig and T cell receptor gene probes has become a valuable addition to morphologic, cytochemical and surface marker studies in determining lineage, clonality, and differentiation of leukemic cell populations [4, 5]. We therefore investigated the diagnostic potential of molecular analyses (a) to develop an understanding of the cellular origin of leukemias which cannot be allocated to one of the defined myeloid or lymphoid lineages by cellular phenotypes, and (b) to reveal the clonal development of phenotypic conversion in acute leukemia.
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