Abstract
AbstractThe Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and presentation to T and B cells. This Report summarizes the key points of that discussion, and subsequent discussions with the Chairs of the other Enterprise Working Groups, the Enterprise Science Committee, the Enterprise Council and the broader scientific community during open sessions at scientific conferences.
Highlights
The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants, and in understanding antigen processing and presentation to T and B cells
An effective HIV vaccine will need to induce durable immune responses that prevent the acquisition of infection and/or reduce viral replication to levels necessary to minimize HIV disease and viral transmission[1,2,3,4]
Designing an immunogen capable of eliciting and maintaining such immune responses remains a major obstacle to the development of an HIV vaccine[2,5,6,7]
Summary
The Global HIV Vaccine Enterprise (the Enterprise) convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants, and in understanding antigen processing and presentation to T and B cells. Priority 1: Study immune mechanisms of protection against HIV infection and disease progression
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