Abstract
Background The ability to induce a broadly neutralizing antibody (bNAb) response following vaccination is regarded as a crucial aspect in developing an effective HIV-1 vaccine. This study describes the design and construction of a subtype C founder virus consensus Env immunogen derived from newly transmitted/founder virus sequences, and its immunogenicity testing in the presence or absence of liganded CD4, in small animals.
Highlights
Immunogenicity of native and CD4 liganded monomeric and trimeric envelope glycoproteins based on HIV-1 Subtype C consensus Founder virus sequences
The ability to induce a broadly neutralizing antibody response following vaccination is regarded as a crucial aspect in developing an effective HIV-1 vaccine
This study describes the design and construction of a subtype C founder virus consensus Env immunogen derived from newly transmitted/founder virus sequences, and its immunogenicity testing in the presence or absence of liganded CD4, in small animals
Summary
The ability to induce a broadly neutralizing antibody (bNAb) response following vaccination is regarded as a crucial aspect in developing an effective HIV-1 vaccine. Immunogenicity of native and CD4 liganded monomeric and trimeric envelope glycoproteins based on HIV-1 Subtype C consensus Founder virus sequences From AIDS Vaccine 2012 Boston, MA, USA. Background The ability to induce a broadly neutralizing antibody (bNAb) response following vaccination is regarded as a crucial aspect in developing an effective HIV-1 vaccine.
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