Abstract
Avian pathogenic Escherichia coli (APEC) cause a wide range of economically significant infections in chickens. Control of these infections by antimicrobial drug is no longer possible due to high prevalence of multidrug resistance strains. Involvement of large number of serotypes in these infections left none serotype specific vaccine as the only option. It has been well established that the Lipopolysaccharide (LP) core specific antibodies are broadly cross protective. Present study determined the LPS core specific antibody titers of chickens immunized with a single dose of heat killed rough mutant E. coli strains comprising of LPS core types R1, R2, R3 and R4. Mean anti-LPS core antibody titres for all four core types increased significantly (p E. coli strains can be used as a vaccine to enhance LPS core specific antibodies in chickens.
Highlights
Colibacillosis caused by Avian Pathogenic Escherichia coli (APEC) is one of the principal diseases that induce various extra intestinal disease manifestations in poultry including septicaemia, enteritis, perihepatitis, pericarditis, peritonitis, synovitis, omphalitis, salpingitis and coligranuloma (Dho-Moulin and Fairbrother, 1999)
Bacterial isolates E. coli isolates used for the study comprised of 143 clinical and 50 commensal isolates
LPS extraction by rapid phenol micro method To screen the collection of 193 E. coli isolates for rough mutants, LPS extracted by rapid phenol micro method (Currie and Poxton, 1999) was used
Summary
Colibacillosis caused by Avian Pathogenic Escherichia coli (APEC) is one of the principal diseases that induce various extra intestinal disease manifestations in poultry including septicaemia, enteritis, perihepatitis, pericarditis, peritonitis, synovitis, omphalitis, salpingitis and coligranuloma (Dho-Moulin and Fairbrother, 1999). These infections cause severe economic losses to the farmer through high mortality, growth depression, cost of antimicrobial therapy and carcass downgrading causing an immense threat to the advancement of the poultry industry (Janßen et al, 2001). Development and use of a potent vaccine appears as the most logical approach to control E. coli infection in poultry
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