Abstract
This study was conducted to compare the immunogenicity and safety of diphtheria–tetanus (Td) vaccine between pre-adolescents aged 11–12 years and adolescents aged 13–18 years. A total of 277 subjects (132 pre-adolescents and 145 adolescents) participated. After vaccination, all subjects (100%) in both groups exhibited seroprotective antibody levels (≥0.1 IU/mL) against diphtheria or tetanus toxoids. Although local adverse events following vaccination were more frequently observed in the pre-adolescent group than in the adolescent group ( p = 0.006), these events resolved within 7 days. Our study shows Td vaccination at age 11–12 years to be immunogenic and tolerable.
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