Abstract
After transfer to tissue culture conditions, transplantable mouse lymphosarcoma cells showed a parallel increase in immunogenicity and in concanavalin A (Con A) directed agglutinability. Injections with cultured tumor cells gave better protection against a challenge with untreated tumor cells than did unmodified, X-ray inactivated cells or cells pretreated with neuraminidase, glutaraldehyde or heat. The preservation of cell integrity following i.p. injection was highest for cultured and fixed tumor cells, but neuraminidase or heat-treated cells were rapidly cleared from the intraperitoneal cavity. The results indicate that the immunogenicity of mouse lymphosarcoma cells was correlated with: (a) the agglutinability with Con A and (b) the persistance of cell integrity following injection. Human leukemia cells transferred in vitro acquired also increased agglutinability with concanavalin A, suggesting a concomitant increase in antigenicity.
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