Abstract
Background The goal of this study was to design structural mimics of HIV-1 epitopes that have the potential to induce broadly neutralizing antibodies (bnAbs). The structure of the gp41 membrane proximal external region (MPER), targeted by three bnAbs, requires further definition. Experiments were designed to select epitopes with enhanced binding to MPER bnAbs, to identify neutralization-competent MPER structures, and to determine if selected MPER epitopes can broaden the immune response as potential vaccines. Methods
Highlights
The goal of this study was to design structural mimics of HIV-1 epitopes that have the potential to induce broadly neutralizing antibodies
Experiments were designed to select epitopes with enhanced binding to membrane proximal external region (MPER) broadly neutralizing antibodies (bnAbs), to identify neutralization-competent MPER structures, and to determine if selected MPER epitopes can broaden the immune response as potential vaccines
This study demonstrates the diversity of epitope recognition by 4E10 and the unique response to MPER in vivo
Summary
The goal of this study was to design structural mimics of HIV-1 epitopes that have the potential to induce broadly neutralizing antibodies (bnAbs). The structure of the gp membrane proximal external region (MPER), targeted by three bnAbs, requires further definition. Experiments were designed to select epitopes with enhanced binding to MPER bnAbs, to identify neutralization-competent MPER structures, and to determine if selected MPER epitopes can broaden the immune response as potential vaccines
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