Abstract
Recent studies have shown that HLA-DR, DQ, DP and CD1a positive cells were related to keloid and hypertrophic scar. Therefore, this study was aimed at investigating the role of immunogenetic factors in the pathogenesis of keloid and hypertrophic scar. The expression levels and distribution patterns of HLA-DR, -DQ, -DP and CD1a molecules in peripheral blood mononuclear cells were determined in 10 samples of keloid, hypertrophic scar, flat scar and normal people with the stain of streptavidin-peroxidase (SP) method. The results show that although the amounts of HLA-DR+, -DQ+, -DP+ and CD1a+ cells had no significant differences among the keloid, hypertrophic scar, flat scar and normal people groups (P>0.05), the integrated optical density (IOD) of HLA- DR+, -DQ+, -DP+ and CD1a+ cells in the keloid and hypertrophic scar were higher respectively, than that in the flat scar and normal people groups (P<0.05). The increased content of HLA-DR, -DQ, -DP and CD1a proteins in peripheral blood of the keloid and hypertrophic scar groups therefore suggest that the over-hyperplasia of scars may be associated with immunogenetic factors. Key words: Keloids, hypertrophic scars, human leukocyte antigen (HLA), CD1a.
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