Immunogenetic characteristics of the clinical course of allergic rhinitis in the UZBEK population depending on the polymorphism of the IL-17A RS2275913 gene

Abstract

Summary Topicality. Over the past decade, according to WHO, there has been an increase in the incidence of allergic diseases. The pathogenesis of allergic diseases is being closely studied, in particular, the role of Th17 cells involved in the pathogenesis of allergic rhinitis and characterized by the predominant synthesis of cytokines IL-17A and IL-17F has been proven. Aim: to study the polymorphism of the IL-17A rs2275913 gene in the Uzbek population and the role in the clinical course, the effectiveness opharmacotherapy of allergic rhinitis with antihistamines. Material and methods. The study included 118 patients with allergic rhinitis. In 112 patients, seasonal allergic rhinitis was diagnosed with an exacerbation in summer (94.9%) and in the spring-summer period of pallination (82.2%). The control group included 200 practically healthy individuals. Genotyping of the IL17A rs2275913 polymorphism was performed using the real-time polymerase chain reaction (Real-Time) "SNP-EXPRESS"-RV method. Results. Patients with allergic rhinitis complained of seasonal and year-round symptoms, which included rhinorrhea, nasal obstruction, sneezing, itching, burning sensation in the nose, sniffling, snoring, apnea, voice change and nasality. I