Abstract
Viral hepatitis B and C is a relevant issue because of high prevalence and degree of chronicity, late diagnosis and poor prognosis. Today, protein products of numerous genes are involved in the pathogenesis of viral pathology of the liver. In this review, the authors analyzed 42 literature sources on genetic basis of susceptibility to various infectious diseases. Study of the role of immunogenetic factors is of great practical importance to develop methods for predicting outcomes of viral hepatitis.
Highlights
The beginning of this century marked the beginning of active study the genetic basis of susceptibility to various infectious diseases
There is enough information showing the importance of dysfunction of enzymes of biotransformation of xenobiotics and antiinflammatory cytokines (TNFa, TGFb) and cytotoxic Tlymphocytes (CTLA4) in the pathogenesis of viral diseases of the liver
CTLA4 is a receptor expressing on the membranes of Tcells, mediates inhibition of the immune response of Tcells [17,18]
Summary
The beginning of this century marked the beginning of active study the genetic basis of susceptibility to various infectious diseases. Because of the close relationship between structure and function of HLA, as well as its role in the immune response, HLAgenes are regarded to be markers with pathogenetic significance in many diseases. CTLA4 (antigen of four cytotoxic Tlymphocytes) is a receptor expressing on the membranes of Tcells, mediates inhibition of the immune response of Tcells [17,18].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
