Immunofluorometrical Exploring of Cortisol Hormone Levels in the Serum of Patients with Histologically Verified Microcellular Lung Cancer

Ivan Milosevic

doi:10.3844/ajisp.2005.12.13

Abstract

It is already known in the science that the cells of microcellular lung cancer can produce ACTH. By following the levels of Cortisol as one consequence of ACTH producing, in the serum of microcellular lung cancer patients, we could make some statistical conclusions how significant these levels would be in eventual future early diagnostic procedures, besides already existing tumormarkers etc. This work would connect the Oncology, Endocrinology and Immunology fields containing very interesting immunofluorometrical procedures, hormonal theories and statistical estimates.

Highlights

The Lung Cancers are malignant tumors of epithelial tissue, fast propagating and giving the bad prognosis
It is already known in the science that the cells of microcellular lung cancer can produce ACTH
By following the levels of Cortisol as one consequence of ACTH producing, in the serum of microcellular lung cancer patients, we could make some statistical conclusions how significant these levels would be in eventual future early diagnostic procedures, besides already existing tumormarkers etc

Summary

INTRODUCTION

The Lung Cancers are malignant tumors of epithelial tissue, fast propagating and giving the bad prognosis. Mitoses are very frequent and that is why the proliferation of those cells is very fast and this histological type rapidly gives the metastases. There are more histological types of microcellular cancer: intermediar, combined, oatcell etc. Microcellular type takes 20% of all Lung Cancers and its cells can secret the ACTH. The anterior part of pituitary gland-adenohipophise, secrets the ACTH and its role is to activate adrenocortical hormones, aldosterone and cortisol. Cortisol stimulates the gluconeogenesis process, mobilizes the fat acids from the fat tissue, has an anti-inflammatory activity etc. On the basis of above presented we can make the following connection: Microcellular lung cancer – ACTH – Cortisol

MATERIALS AND METHODS

Findings

CONCLUSION