Abstract
The immunofluorescent antibody technique was used to assay type-specific herpes simplex virus antibodies. Antibody responses were studied in three groups of patients: children with primary herpetic infections, neonates with generalized type 2 infection and adults with genital herpes infections. The results were compared with antibody responses seen in rabbits after experimental type 1 and 2 infections. In both rabbits and children with primary herpetic infections there was considerable cross-reaction, while in patients with genital herpes infections and in neonates there was very little cross-reaction.
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