Immunofluorescence studies on the effect of cyclic adenosine 3',5'-monophosphate in tissue cultue preparations of the cervicovaginal anlage from neonatal mice.

Abstract

The authors have studied the production of antigenic material, specific for the cervicovaginal epithelium, in organ cultures of the cervicovaginal region from neonatal mice. In control cultures the antigenic material appeared at a time corresponding to the normal appearance under in vivo conditions. When cyclic adenosine 3′, 5′-monophosphate (dibutyryl derivate) was added to the medium, a strong increase of the fluorescent material was seen.