Abstract
Odontogenic keratocysts (OKCs) are clinically aggressive lesions with relatively high recurrence rates. Dysregulation of functional equilibrium in the RANK/RANKL/OPG system is responsible for osteolysis associated with the development of OKCs. Previously published findings imply that immunoexpression of these 3 proteins may correlate with bone resorption activity in OKCs. The rationale behind this study was to assess the potential for receptor activator of nuclear factor kappa-B (RANK), receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG) expression, as well as RANKL/OPG expression ratio, to serve as prognostic indicators for OKC recurrence. We investigated the immunoexpression patterns of RANK, RANKL and OPG, and their correlation with recurrence rates, in 41 patients with OKCs treated with enucleation. We found no statistically significant differences between recurrent and non-recurrent cysts in terms of either: epithelial (p = 0.404) and stromal (p = 0.469) immunoreactivity of RANK; epithelial (p = 0.649) and stromal (p = 0.198) immunoreactivity of RANKL; or epithelial (p = 1) and stromal (p = 0.604) immunoreactivity of OPG. We also did not find significant differences in the distribution of cases with respect to ratios of RANKL/OPG immunostaining scores between recurrent and non-recurrent OKCs, both in the epithelium and in the connective tissue (p = 1 and p = 0.237, respectively). Our results suggest that immunoexpression levels of RANK, RANKL and OPG at the time of pathological diagnosis, as well as the RANKL/OPG ratio, are not useful as prognostic markers for OKC recurrence.
Highlights
Odontogenic keratocysts (OKCs) are clinically aggressive lesions with relatively high recurrence rates
Our results suggest that immunoexpression levels of receptor activator of nuclear factor kappa-B (RANK), receptor activator of nuclear factor kappa-B ligand (RANKL) and OPG at the time of pathological diagnosis, as well as the RANKL/OPG ratio, are not useful as prognostic markers for OKC recurrence
We demonstrated that expression levels of COX-2, BCL-2 (B-cell lymphoma 2), PCNA, and tumor protein p53 are not associated with OKC recurrence.[4]
Summary
Odontogenic keratocysts (OKCs) are clinically aggressive lesions with relatively high recurrence rates. The World Health Organization (WHO) reclassified KCOT from the tumor category into the cyst category as odontogenic keratocyst (OKC).[1] published reports stress the significance of its aggressive growth and relatively high recurrence rate It has been suggested that expression of epithelial cell proliferation and apoptosis markers might be correlated with propensity for OKC recurrence, but these results are ambiguous. We demonstrated that expression levels of COX-2 (cyclooxygenase-2), BCL-2 (B-cell lymphoma 2), PCNA (proliferating cell nuclear antigen), and tumor protein p53 are not associated with OKC recurrence.[4] it is essential to continue to investigate other molecular factors in the search for prognostic candidates
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
