Abstract
This study evaluated the immunoexpression of HIF-1α and correlated it with intratumoral and peritumoral lymphatic density in metastatic and non-metastatic lower lip squamous cell carcinoma (LLSCC). Study Design: This study evaluated the expression pattern and the percentage of cells immunostained for HIF-1α in 50 cases of LLSCC; 25 had regional nodal metastasis and 25 did not. Lymphatic microvessel density was determined. Results: HIF-1α exhibited predominantly diffuse cytoplasmic staining in tumors.
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