Immunoenhancement of Edible Fungal Polysaccharides (Lentinan, Tremellan, and Pachymaran) on Cyclophosphamide-Induced Immunosuppression in Mouse Model.

Qian Zhang,Xiangliang Yang,Minghua Hu,Yanhong Zhu,Renhuai Cong

doi:10.1155/2017/9459156

Abstract

Fungal polysaccharides display a variety of important biological activities, including anti-inflammatory, antitumor, and immune-stimulating activities. The aim of present study was to investigate the immunomodulatory effect of fungal polysaccharides on cyclophosphamide-induced immunosuppression in mice. Mice were pretreated orally with lentinan, tremellan, pachymaran, or a mixture of the three, respectively. The results showed that pretreatments with polysaccharides significantly increased the thymus index in cyclophosphamide-induced immunosuppression mice. The level of the cytokine IL-10 in sera of cyclophosphamide-induced mice was decreased after pretreatments of polysaccharides. Flow cytometry results showed that pretreatments with polysaccharides enhanced the phagocytosis of peritoneal macrophages in mice. The increased levels of serum antibody IgG and IgM were observed in the groups pretreated with polysaccharides. Our work demonstrated that the treatment of polysaccharides elicited strong immune activity and a protective effect against cyclophosphamide-induced immunosuppression.

Highlights

In everyday life, working pressure, pollution, immunosuppressive agents, and so on are the causes of lower immunity and subhealth [1]
We investigated the effects of polysaccharides on immune suppression in the cyclophosphamide-induced mouse model
Thymus index and spleen index in the model group were decreased significantly, whereas these indexes were increased after treatment with polysaccharides (Figure 2)

Summary

Introduction

In everyday life, working pressure, pollution, immunosuppressive agents, and so on are the causes of lower immunity and subhealth [1]. Improving immunity to prevent diseases has long been one of the primary concerns for many researchers. The use of immune modulators to enhance the host defense responses can be an effective way to increase resistance to disease [2, 3]. Fungal polysaccharides have been explored for their broad spectrum of biological activities with relatively low toxicity and adverse effects [2, 4,5,6,7]. Some polysaccharides have been known to improve the immunity by activating immune-related cells, or promoting antibody production [2, 8]. Polysaccharides have received extensive attention in the fields of therapeutics

Methods

Results

Conclusion