Abstract
The distribution of fibres and cell bodies containing angiotensin-II in brainstem respiratory nuclei was studied using an indirect immunoperoxidase technique. In order to visualize immunoreactive perikarya, intracerebral injections of colchicine were carried out. The richest cluster of immunoreactive perikarya was localized in the Bo¨tzinger complex and Ko¨lliker-Fuse areas, whereas in the nucleus ambiguus and nucleus retroambiguus a moderate density of cell bodies was observed. The nucleus tractus solitarius (ventrolateral portion) and the nucleus parabrachialis medialis had the lowest number of immunoreactive neurons. Angiotensin-II containing fibres were abundant in the nucleus parabrachialis medialis, Bo¨tzinger complex and Ko¨lliker-Fuse area, and scarce in the nuclei tractus solitarrius (ventrolateral part), ambiguus and retroambiguus. Moreover, in the dorsal motor nucleus of the vagus a dense network of immunoreactive fibres and a large number of cell bodies were observed. The presence of angiotensin-II in respiratory areas suggests a role for this octapeptide in controlling respiration.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
