Abstract
An affinity-purified anti-peptide antibody generated against the carboxy-terminal region of the δ opioid receptor was used to localize δ opioid receptors in mouse brain. δ Opioid receptor immunoreactivity was found in axons and nerve terminals in regions of the olfactory bulb, hippocampul formation, cerebral and cerebellar cortex, midbrain and hindbrain. The immunocytochemical distribution correlated well, though not completely with autoradiographic distribution of δ opioid receptors in mouse brain using either [ 3H][2- d-penicillamine, 5- d-penicillamine]-enkephalin (DPDPE) or [ 3H]naltrindole. Confocal microscopy of double-labeled tissue provided direct evidence that δ opioid receptors are principally expressed on GABAergic terminals in the hippocampus. These anatomical findings complement extensive physiological studies to provide a more detailed description of endogenous opioid circuitry.
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