Abstract
Complement system and granulocytes are both important effecters in host defence mechanism. Murine peritoneal neutrophils elicited with Streptococcus preparation (OK432) was found to synthesize and secrete the third component of complement (C3). In this report the localization of C3 in the neutrophils was investigated by immunoelectron microscopy. C3 was found predominantly in vesicles which might be the counterpart of the most easily mobilizable secretory vesicles of human neutrophils. Murine eosinophils from peritoneum elicited with OK432 were found for the first time to contain C3 and to be localized in their crystalline granules.
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