Abstract
Summary Antibodies to the gastrin molecule were evoked in rabbits by immunization with synthetic human gastrin I (2–17) conjugated to bovine serum albumin. The antibodies produced were of the γG-immunoglobulin class. A radioimmunoassay system for gastrin is described utilizing the precipitation of antibody-bound radioiodinated synthetic human gastrin I (2–17). The sensitivity of the immunoassay method is 5 μμg, a level of sensitivity anticipated to be sufficient to measure physiological levels of gastrin in human serum.
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