Abstract
Antigenic polysaccharide-peptide complexes were extracted from mycelia of Trichophyton mentagrophytes, and purified by gel filtration, DEAE-cellulose and proteolytic digestion. The chemical composition of crude and purified antigens is described. Purified antigens were composed chiefly of carbohydrate material, mainly glucose or mannose, with smaller amounts of galactose, glucosamine and peptides. The antigens were further evaluated by skin test in humans with naturally acquired trichophytosis, especially tinea pedis.Proteolytic digestion caused the N content of the polysaccharide-peptide complexes to fall from 1/7 to 1/8. Such peptide degradation caused a loss of the delayed reaction in skin tests. It did not, however, cause a reduction in the immediate reaction in skin tests or a disappearance of precipitin arcs in agar gels.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
