Abstract
Abstract Immunodiffusion and inhibition studies indicated that 19S class guinea pig antibodies to foot-and-mouth disease virus were specific for distinctive antigenic determinants on the virus particles, whereas 7S antibodies had a single specificity for the virus particles and were unable to discriminate between the different individual antigenic determinants. This was interpreted as meaning that the antigenic determinant site encompassed by 7S antibodies consists of several smaller regions (subdeterminants) each of which may serve as an antigenic determinant site for 19S antibodies. It was also proposed that the combinding sites of 19S antibodies are smaller than those of 7S antibodies.
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