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Abstract
Water-soluble carbodiimides and a benzisoxazolium salt were used to synthesize conjugates containing angiotensin coupled to albumin or poly- l-lysine. antibodies to angiotensin were induced with a conjugate containing the hormone bound to rabbit serum albumin. The antigenic determinants of angiotensin were investigated by inhibition of complement fixation by analogues of the polypeptide. Among the structural features of angiotensin tested, those which had greatest importance for serologic activity were conformation as determined by an optical isomer in the middle of the hormone molecule: the presence of the two amino acids at the N-terminus; and the single phenolic hydroxyl. The structural features shown to be important for serologic activity were those previously shown to be important for biological activity.
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