Abstract
Immunochemical procedures were applied to an evaluation of antigenicity of house dust extract. A dermal wheal reaction to house dust extract was invariably accompanied by release of histamine from the subject's leukocytes exposed to the extract in vitro; when no dermal reaction occurred, histamine was not released. Scrum of every subject with a dermal wheal reaction to house dust extract was able to neutralize the antigenic activity of the extract to some degree, while serum of nonreactive persons did not. Serial injections of house dust extract produced up to 56-fold increases in specific antigen neutralization capacity of the serum in a small portion of hypersensitive subjects who received unusually large amounts, but the leukocytes were not desensitized to antigenic release of histamine. The findings support the contention that house dust contains immunologically specific antigen'e material capable of causing specific hypersensitivity and provoking specific immune response upon injection in atopic persons. The clinical implications are considered.
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