Abstract
A comparative study has been made of the precipitating and non-precipitating sheep antibodies in the γ 1 and γ 2 immunoglobulin fractions. The γ 1 precipitating and non-precipitating antibodies possess heterocytotropic activity and are able to fix complement, while those of γ 2 possess homocytotropic activity and do not fix complement. It is only the γ 1 precipitating antibody that originate a reverse Arthus phenomenon. All precipitating and non-precipitating antibodies are capable of agglutinating specifically sensitized sheep red cells. The non-precipitating antibodies purified by immunoadsorption are bivalent and make their appearance throughout immunization until representing 10–15% of the total antibodies. While the K 0 values of γ 1 and γ 2 non-precipitating antibodies are lower than those corresponding to precipitating antibodies, such values increase progressively and are never sufficiently low to consider them responsoble for the non-formation of insoluble complexes with the antigen on the part of non-precipitating antibodies.
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