Abstract
Results The patient (smoker) complained on a variety of symptoms that were bothering her for more than 3 years: headaches, significant fatigue, nasal blockage, breathlessness on exercise and occasionally at rest. There were no ocular symptoms. She had several courses of antibiotics during this period with slight improvement. Careful history revealed progressive deterioration in her condition; there was no difference in her symptom pattern through the season although she noted that she had more sinus pains in winter. There was a dog, but no dampness in the house. There was no personal or family history of atopy. Anterior rhinoscopy had appearance of acute inflammation with no structural abnormalities. Spirometry showed FEV1 95%, FVC 92% and Peak flow 85% predicted. Skin prick test with valid controls, was negative to a standard panel of aeroallergens including dog. Immunocap ISAC test was offered to broaden the spectrum of allergens tested. This showed mono-sensitisation to Dog rCan f 5 Arginine esterase 1,5 ISU and negative to all other components.
Highlights
Recent developments in immunology have started to influence clinical allergy by introducing a promising approach of molecular allergy - ImmunoCap ISAC
Aim We present a unique case of severe allergic rhino-sinusitis in a 39 y.o. female patient that was diagnosed using ISAC
ISAC is designed to detect specific IgE antibodies to a large number of allergenic epitopes – components of known allergens from a single blood test
Summary
Recent developments in immunology have started to influence clinical allergy by introducing a promising approach of molecular allergy (allergology) - ImmunoCap ISAC. Immunocap ISAC as an important diagnostic tool in rhino-sinusitis Michael Rudenko1*, Suranjith Seneviratne1, Robert Boyle1, Katya Burova1, William Egner2, Amina Bhayat-Cammak3, Neal Bradshaw4 From 9th Symposium of Experimental Rhinology and Immunology of the Nose (SERIN 2013) Leuven, Belgium.
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