Abstract
The S100A8 and S100A9, also known as myeloid-related protein 8 (MRP8) and MRP14, are members of the S100 protein family [1-3]. Like other S100 proteins, which includes 25 family members, S100A8 and S100A9 have two conserved Ca<sup>2+</sup> binding domains connected by a variable hinge region thought to regulate its biological activity and is distinct for each family member.
Highlights
Aspergillus fumigatus is a saprophyte fungus that survives and grows over a large variety of organic remains and whose most common ecological niche is on the ground
The objective of the current study was to evaluate whether Toll-Like Receptor 2 (TLR2) and TLR4 levels increase in the lung tissue of a murine model of neutrophil airway inflammation
We evaluated the effect of A. fumigatus spores on the
Summary
Aspergillus fumigatus is a saprophyte fungus that survives and grows over a large variety of organic remains and whose most common ecological niche is on the ground. It is one of the most ubiquitous fungi due to the ease of dispersion of its conidia [1]. Aspergillus, a ubiquitous mold, affects the respiratory system in more ways than one. The clinical spectrum of Aspergillus-associated hypersensitivity respiratory disorders includes Aspergillus-induced asthma, allergic bronchopulmonary aspergillosis (ABPA), and allergic Aspergillus sinusitis, which are usually observed in atopic subjects [3]. A. fumigatus produces a significant number of allergenic molecules that react with IgE in asthmatic patients and in patients with ABPA [4]
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