Immunoaffinity purification and characterization of specific antibodies against recombinant tau protein from intravenous immunoglobulin product

Abstract

There is evidence that humoral immunity is involved in some processes associated with neurodegenerative diseases. Antibodies against many molecules occurring predominantly in brain tissue are detected also in cerebrospinal fluid as well as in plasma and serum. One of these molecules is tau protein, the integral component of paired helical filaments (PHF) which were identified as the major part of neurofibrillary pathology in Alzheimer's disease (AD). It is also known that specific antibodies against tau protein are contained in intravenous immunoglobulin (IVIG) products.