Abstract
Malaria a protozoan parasite disease confined mostly to the tropical areas caused by Plasmodium parasites & transmitted by Anopheles mosquito. This parasite mainly infect in blood of human being. Antigenic protein of Plasmodium falciparum i.e.pfM18AAP is a metalloaminopeptidase that function in affecting complete degradation of host haemoglobin. Hence vaccination with pfM18AAP protein would be ideal for disease prevention. The second major feature of malarial pfM18AAPprotein is its capacity to induce neutralizing antibodies and protective immunity, and it is thereby considered as a potential target for vaccine development. In this present study, an effort was taken to design a candidate vaccine applying the techniques of vaccinology. The method includes identification of potential candidate vaccine, epitope prediction, peptide designing, and energy evaluation of the candidate vaccine followed by validation study. The high scoring vaccine candidate was selected .The result revealed that the designed candidate vaccine has a high binding affinity with T-cell receptor. Keywords: -Malaria, Vaccine, Epitope, Vaccinology, Metalloamino peptidase,
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