Immuno-biological Rationale for the Use of Platelet-rich Donor Plasma for the Regional Treatment of Wounds

Abstract

There has recently been great interest in platelet growth factors. Universal mechanism of action, simplicity, low cost and maloinvazivnogo receiving expand their use in practical medicine. However, comorbidities and the technical difficulty of isolating platelets from autoplasma are the limiting factors for widespread adoption of the techniques in the daily work of doctors of most hospitals. The article listed the main drugs of platelets enriched plasma (pure platelet-rich plasma enriched with white blood cells and platelets blood plasma, pure platelet-enriched fibrin enriched with platelets, leukocytes and fibrin), the features, the conditions of their production and hardware by apheresis, and from the pool leykotrieny layers. The marked advantages of automatic separation of blood components, which minimizes the human factor in (avoiding manual labor), allows to distinguish the platelets of high quality with little loss of hemoglobin and plasma, ensures quick and accurate obtaining of necessary blood components and the shelf life of platelets, the importance of timely delivery. The authors considered immune and biological aspects of the use of donor platelet concentrate. Describes methods to reduce the risks of transmission of hemotransmissive infections, alloimmune effects, bacterial contamination of wounds with local application of platelet concentrate. Comparative evaluation of the economic component of the latest hardware by apheresis and from the pool leykotrieny layers. The use of platelet-rich donor plasma for the stimulation of reparative processes in the healing of nonhealing wounds is due to equivalent clinical effectiveness of the use of donor platelet concentrate and platelet-rich autoplasma. Convenience of centralized procurement allows greater use of platelet drugs in many hospitals.