Abstract
Rhesus monkeys were immunized with concentrated suspensions of monkey erythrocytes infected with Plasmodium knowlesi, or with parasites freed from their host erythrocytes. Vaccination with the antigen material alone conferred no protection. Subcutaneous inoculation of the vaccines combined with Freund's adjuvant produced variable results. Intramuscular injection of the killed parasites and the adjuvant conferred a strong immunity against a challenge infection. The protected animals showed a marked increase in the levels of serum gamma globulin but, since some of the animals which were not protected also showed an increase in the gamma globulin, much of the additional globulin was thought to be non-specific and/or non-protective.
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