Abstract

Summary11 Rh‐negative volunteers were repeatedly given very small doses of Rh‐positive cells; 8 were given doses of 0.01 ml and 3 were given doses of 0.1 ml on each occasion. Under this regime, 7 volunteers developed Rh antibodies; 1 was doubtfully immunized; and in 3 people, Rh antibodies could not be demonstrated. In these non‐responders, even increased booster doses appear to have no effect.

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