Immunization of man with salmonella vaccine and tetanus-diphtheria vaccine. Dose-response relationship, secondary response, and competition of antigens

Abstract

Immunization of men with various amounts of salmonella antigens gave a linear relationship between the logarithm of the dose and the logarithm of the titres of the antibodies produced. No secondary response was observed for any of the doses used. These doses of salmonella vaccine did not interfere with or stimulate simultaneous primary or secondary vaccination with tetanus and diphtheria vaccine.